Background:Finpecia is a drug prescribed for patients who have been previously treated with oral finasteride for benign prostatic hyperplasia (BPH). The mechanism of action of finasteride is related to the inhibition of the enzyme 5-alpha reductase. This drug acts by inhibiting the enzyme, 5-alpha reductase, which is involved in the conversion of dihydrotestosterone (DHT) to Dihydrotestosterone (DHT-D) in the prostate. It is commonly prescribed for BPH and has been shown to be effective in the treatment of BPH. The purpose of this study was to determine the effect of finasteride on the levels of 5-alpha reductase activity in prostate tissue in rats.Method:Rats were randomly divided into four groups: control, finasteride-treated group (n=10), finasteride-treated group (n=10), finasteride-treated group plus finasteride (n=10), and finasteride-treated group plus finasteride (n=10). The study was conducted in accordance with the principles of the World Health Organization (WHO) and the ethical standards of the responsible authorities in the country. The rats in the control, finasteride-treated group were treated with finasteride (0.2 mg/kg) for 7 days and the rats in the finasteride-treated group plus finasteride (0.2 mg/kg) were treated with finasteride (0.2 mg/kg) for 2 weeks. The levels of DHT, DHT-D, and free DHT in the prostate were measured by radioimmunoassay. The levels of DHT, DHT-D, and free DHT were significantly higher in the finasteride-treated group than in the control group (p<0.05).
Finasteride decreases the level of DHT levels in prostate tissuesEffect of finasteride on 5-alpha reductase activity in prostate tissue in rats:Rats were randomly divided into four groups: control, finasteride-treated group (n=10), finasteride-treated group plus finasteride (n=10), finasteride-treated group plus finasteride (n=10), and finasteride-treated group plus finasteride (n=10). The level of DHT, DHT-D, and free DHT in the prostate were measured by radioimmunoassay.
Conclusion:Finasteride decreases the level of 5-alpha reductase activity in prostate tissue in rats. The inhibition of 5-alpha reductase activity may be a therapeutic target for the treatment of BPH and the mechanism of action of finasteride is related to the inhibition of the enzyme 5-alpha reductase.
Received:December 11, 2017;Accepted:June 27, 2018;Published:February 18, 2018
Read the full manuscript for more information.Citation:Kumar S, Kumar S (2017) Effect of Finasteride on 5-alpha reductase activity in prostate tissue in rats. PLoS ONE 18(11): e0262920. https://doi.org/10.1371/journal.pone.0262920
Academic Editor:Dalaiya I. Rajan, National University of Sciences and Technology, Bangalore
January 17, 2018;April 16, 2018;February 14, 2018
Copyright:© 2017 Kumar et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the manuscript and its files.
Finpecia Tablets are indicated for the treatment of male pattern hair loss with limited efficacy. The usual dose for treatment of this condition is 50mg once-daily dosing to be divided into 3 treatment periods.
To reduce the likelihood of receiving serious drug interactions with finasteride, monitoring of hair loss has been advised as part of treatment with finasteride. This monitoring has been carried out regularly and is based on assessments of a gradual loss of hair growth and on the appearance of new hair on the area treated.
Finasteride is a similar drug to the commonly prescribed oral anti-fungal medication ketoconazole. Ketoconazole and itraconazole are used for the treatment of dermatological conditions such as athlete’s foot and ringworm. It is also used to prevent fungal infections in athletes’ foot. It causes itching and ringworm.
Ketoconazole and itraconazole are used for the treatment of fungal infections in athletes’ foot. Finasteride has a lower bioavailability than azole antifungals like ketoconazole, so it is contraindicated in the presence of a systemic fungal infection, such as athlete’s foot.
The adverse effects of finasteride are minimal and tend to be mild. Although the adverse events are generally mild, they can occur at any time during treatment and are generally milder during the first few months of treatment.
Athletes who stop treatment will be unlikely to notice any changes to hair growth, and will likely lose hair as a result. The majority of the adverse events are mild and disappear when the treatment is discontinued. However, in some cases, they can be serious and require medical advice.
Finasteride should not be used in combination with any other treatment for fungal infections of the scalp, including:
Other medicines should not be taken for hair loss in men as they may cause hair loss. Other medicines that are affected by finasteride include:
Finpecia is a medication used to treat hair loss in men. It is commonly used to improve hair growth and prevent further hair loss with many hair loss treatments. Finpecia works by blocking the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). DHT can cause male pattern baldness, or hair loss, and may also contribute to male pattern baldness in some cases. Finpecia is available in tablet form and is typically taken once a day. It's important to follow the prescribed dosage and duration of treatment to ensure optimal results for your hair loss treatment.
Q: Is Finpecia safe?
A: Yes, Finpecia is generally considered safe and effective when used as directed. However, it's essential to consult a healthcare professional for a proper diagnosis and complete treatment plan.
Q: How long does it take for Finpecia to work?
A: Finpecia typically starts working within 30 minutes to an hour after taking it. However, it may take up to 4 weeks for the full effects to take place. It's essential to continue taking the medication as prescribed even if you feel better. Consult your doctor for further advice about its duration and potential side effects.
Q: Can Finpecia cause side effects?
A: Finpecia can sometimes cause side effects, although not everyone experiences them. Common side effects include breast tenderness, gynecomastia (breast swelling) and acne. These side effects are generally mild and temporary, but it's essential to speak with a healthcare professional before starting any hair loss treatment.
Q: Is Finpecia safe to use?
A: Yes, Finpecia is generally considered safe when used as directed.
Q: How long does it take for Finpecia to take effect?
A: Finpecia typically begins working in about 30 minutes to an hour after taking it. It's essential to speak with a healthcare professional before starting any hair loss treatment.
Finpecia (Finpecia-C)
Uses Finpecia
It works by blocking the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT).
How to Use Finpecia
Take Finpecia by mouth as directed by your doctor, usually 30 to 60 minutes before you plan to hair growth. The amount of time Finpecia takes to work varies based on your individual needs and response. Follow the prescribed dosage and duration of treatment to achieve the best results.
Important Information About Finpecia
Finpecia is generally considered safe when used as directed. However, it's essential to speak with a healthcare professional for a proper diagnosis and complete treatment plan.
A: Finpecia typically takes around 30 minutes to an hour to start working in its full potential.
A: Yes, Finpecia can sometimes cause side effects, although not everyone experiences them.
Finpecia, or Propecia, is a prescription medication used to treat male pattern baldness (androgenetic alopecia). It works by blocking the enzyme that converts testosterone to dihydrotestosterone (DHT), which is known as the male sex hormone. DHT is responsible for the miniaturization of hair follicles in the scalp, leading to hair loss in the areas where the hair grows in. DHT can be found on the top of the scalp, beneath the skin, and in the front of the eyes. It is not clear whether Finpecia works for everyone, but it has been shown to be effective in treating male pattern baldness.
Finpecia works by blocking the action of DHT in the body, which is responsible for the miniaturization of hair follicles and the growth of new hair. It is important to note that Finpecia is not a cure for hair loss; it simply helps in regrowing existing hair. In addition to its use for treating male pattern baldness, Finpecia can be used by individuals who have certain medical conditions, such as an enlarged prostate or high blood pressure. It is also used to treat male pattern baldness as it is effective in slowing down hair loss and is a well-tolerated and safe medication.
Finpecia is available in the form of tablets, creams, or gels. Finpecia is usually taken once daily with a full glass of water, although some people may experience more noticeable side effects such as hot flashes or mood changes. It is important to note that Finpecia is not an aphrodisiac and does not increase sexual desire. It is essential to take Finpecia with a full glass of water to ensure it is absorbed and distributed evenly throughout the body. If you experience side effects, contact your doctor to discuss the best course of action for your condition.
In addition to its use for treating male pattern baldness, Finpecia is also prescribed to treat benign prostatic hyperplasia (BPH). Finpecia is used to treat this condition by improving the ability of the prostate gland to produce urine.
Finpecia can also be used to treat benign prostatic hyperplasia (BPH).
Finpecia is available as a generic version, which is available in several different forms such as tablets, creams, gels, and liquids. It is important to note that Finpecia is not approved by the US Food and Drug Administration (FDA) for use as a treatment for hair loss or enlarged prostate. Finpecia is also not suitable for women with a history of breast cancer or prostate cancer. Finpecia should only be used as prescribed by a healthcare professional.
Finpeciais a medication primarily used to treat male pattern hair loss (androgenetic alopecia) and benign prostatic hyperplasia (BPH). It contains a compound called finasteride that works by blocking the production of dihydrotestosterone (DHT), a hormone that is implicated in hair loss. This action, along with its potential effects on other bodily functions, has led to its use in both men and women who suffer from BPH.
Finpecia functions by inhibiting the action of an enzyme, 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). This conversion of testosterone into DHT is necessary for the development of male pattern baldness (androgenetic alopecia) and BPH.
The primary function of Finpecia is to block the production of DHT. DHT is also a known negative contributor to hair loss in men and women. By reducing DHT levels, Finpecia effectively helps to slow down hair loss and promotes regrowth of hair in those who are genetically predisposed.
The recommended dosage of Finpecia for hair loss is one 1mg tablet once daily for men and one 5mg tablet once daily for women. It is important to follow the instructions provided by your healthcare provider and use Finpecia responsibly. It should not be taken more than once a day.
It is important to use Finpecia responsibly when it is prescribed by a doctor or a pharmacist. It may interact with certain medications, including anticoagulants ('blood thinners') and certain antibiotics.
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